Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insertion of Single-pass Transmembrane Proteins in the RER01:26

Insertion of Single-pass Transmembrane Proteins in the RER

18.2K
Integral membrane proteins are proteins adhered to the lipid bilayer of a cell organelle or membrane. They can be of two types: transmembrane integral proteins that span the lipid bilayer and monotopic proteins that are attached to either side of the membrane but do not pass through it.
Integral transmembrane proteins possess transmembrane and extra membrane domains. The transmembrane domains are primarily made of 20-25 hydrophobic amino acids arranged in a helical secondary confirmation. These...
18.2K
Lattice Centering and Coordination Number02:33

Lattice Centering and Coordination Number

12.4K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
12.4K
Center of Gravity00:58

Center of Gravity

6.8K
The center of gravity (COG) of an object is the point where the object's total weight is considered to be concentrated. Knowing the location of the center of gravity is useful when predicting the behavior of a moving object or designing static structures. In a uniform gravitational field, the center of gravity is similar to the center of mass (COM); yet, these two points can be positioned differently. For example, the Moon's center of mass lies very close to its geometric center, but...
6.8K
Center of Gravity01:15

Center of Gravity

2.2K
The center of gravity is the point at which an object's weight appears to be concentrated and can be used to balance the object perfectly. This point is essential in mechanics as it provides information regarding a body's stability and moments of inertia. The center of gravity does not always have to fall within the shape or boundaries of the body; it may also lie outside the body in certain cases.
To determine its location, the principle of moments can be utilized by dividing the object into...
2.2K
Center of Mass00:59

Center of Mass

2.1K
The center of mass is the point at which the total mass of an object can be said to be concentrated. It is a fundamental principle in mechanics and physics that applies to all objects regardless of their shape or size. The center of gravity is the point at which an object’s weight appears to be concentrated and can be used to balance the object perfectly.
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...
2.1K
What is an Experiment?01:12

What is an Experiment?

19.1K
An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
19.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[From Bite to Loss of Vision-Ocular Complications of West Nile Virus].

Die Ophthalmologie·2026
Same author

Functional assessment of the XEN<sup>®</sup> Gel Stent relative to the implant position using non-invasive stress testing and automated gonioscopy.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Toxoplasmosis meets the World Health Organization criteria for a neglected tropical disease.

PLoS neglected tropical diseases·2026
Same author

Immune Checkpoint Inhibitor-Associated Uveitis Treated with the 0.19 Mg Fluocinolone Acetonide Intravitreal Implant: Clinical Outcomes in a Retrospective Case-Series.

Ocular immunology and inflammation·2026
Same author

TRP-Dependent Calcium Regulation in HCEC-12 Cells: Involvement of Ascorbic Acid and Cannabinoid Receptor Signaling.

International journal of molecular sciences·2026
Same author

Bilateral visual impairment caused by Toxoplasma gondii encephalitis and ocular GVHD in a patient after allo-HSCT.

Journal of ophthalmic inflammation and infection·2026

Related Experiment Video

Updated: Feb 14, 2026

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience
09:51

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience

Published on: December 4, 2023

1.7K

Dexamethasone Inserts in Noninfectious Uveitis: A Single-Center Experience.

Dominika Pohlmann1, Gerrit A Vom Brocke1, Sibylle Winterhalter1

  • 1Charité - Department of Ophthalmology, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Ophthalmology
|February 21, 2018
PubMed
Summary

Repeated intravitreal dexamethasone (DEX) inserts effectively reduced cystoid macular edema and vitreous haze in noninfectious uveitis patients. Visual acuity improved, with manageable ocular side effects like transient intraocular pressure spikes.

More Related Videos

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

3.2K
Structured Approach to Colonoscopy Technique Optimization: A Single-Center Experience with Novice Endoscopists
03:43

Structured Approach to Colonoscopy Technique Optimization: A Single-Center Experience with Novice Endoscopists

Published on: July 11, 2025

802

Related Experiment Videos

Last Updated: Feb 14, 2026

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience
09:51

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience

Published on: December 4, 2023

1.7K
Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

3.2K
Structured Approach to Colonoscopy Technique Optimization: A Single-Center Experience with Novice Endoscopists
03:43

Structured Approach to Colonoscopy Technique Optimization: A Single-Center Experience with Novice Endoscopists

Published on: July 11, 2025

802

Area of Science:

  • Ophthalmology
  • Clinical Medicine
  • Pharmacology

Background:

  • Noninfectious uveitis can cause significant vision impairment, often involving cystoid macular edema and vitreous haze.
  • Intravitreal corticosteroids are a common treatment for ocular inflammation, but long-term efficacy and safety require further investigation.

Purpose of the Study:

  • To evaluate the effectiveness of repeated intravitreal dexamethasone (DEX) inserts in managing noninfectious uveitis.
  • To assess the impact of DEX inserts on visual acuity, retinal thickness, and vitreous inflammation.

Main Methods:

  • A prospective, single-center interventional trial involving 76 patients (109 eyes) with noninfectious uveitis.
  • Patients received 700-μg intravitreal DEX inserts, with follow-up at 1, 3, and 6 months.
  • Key outcomes measured included best-corrected visual acuity (BCVA), central retinal thickness (CRT), vitreous haze (VH) score, and intraocular pressure (IOP).

Main Results:

  • Repeated DEX inserts led to significant reductions in CRT (P < 0.001) and improvements in BCVA and VH.
  • Patients with idiopathic uveitis and sarcoidosis showed good response; those on no systemic treatment or on antimetabolites/cyclosporin A had the greatest benefit.
  • A transient increase in IOP was observed post-injection, but ocular complications were generally reversible.

Conclusions:

  • Repeated intravitreal DEX inserts are effective for improving visual acuity and reducing inflammation in noninfectious uveitis.
  • Treatment outcomes can be influenced by the underlying uveitis etiology and concurrent systemic therapies.
  • While generally safe, potential ocular complications such as cataract formation should be monitored.