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Proton Therapy for Craniopharyngioma - An Early Report from a Single European Centre
T Ajithkumar1, A-L Mazhari2, M Stickan-Verfürth3
1Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Aims:
Proton beam therapy (PBT) is being increasingly used for craniopharyngioma. We describe our early outcome of patients treated with PBT.
Materials And Methods:
Between August 2013 and July 2016, 18 patients with craniopharyngiomas were treated with 54 Cobalt Gray Equivalent (CGE) in 30 fractions over 6 weeks at our centre. The early outcome of 16 patients included in a registry study was analysed. Radiological response was assessed by RECIST criteria and the disease- and treatment-related toxicities were scored according to the CTCAE 4.0.
Results:
All patients are alive at a median follow-up of 32.6 months (range 9.2-70.6 months) from initial diagnosis. The median age at PBT was 10.2 years (range 5.4-46.9 years). One patient progressed 8.7 months after PBT and subsequently had complete resection of the tumour. At a median follow-up of 18.4 months after PBT, five patients remained in complete remission, four in partial remission and seven with stable disease. The most common adverse effects during PBT were grade 1 (cutaneous in seven patients and fatigue in six patients). There were no treatment-related grade 3 toxicities.
Conclusions:
Our early results are encouraging and comparable with the limited literature on PBT for craniopharyngioma.
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