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Hepatoblastoma incidence in Taiwan: A population-based study
Giun-Yi Hung1, Li-Yih Lin2, Ting-Yen Yu3
1Department of Life Science, National Taiwan Normal University, Taipei, Taiwan, ROC; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Pediatrics, National Yang-Ming University School of Medicine, Faculty of Medicine, Taipei, Taiwan, ROC.
Hepatoblastoma incidence in Taiwan is low, primarily affecting young children, with a notable increase in boys. Adult cases are rare, requiring further research into molecular causes and the link to prematurity survival.
Area of Science:
- Pediatric Oncology
- Cancer Epidemiology
Background:
- Hepatoblastoma incidence data in Taiwan is limited.
- This study aimed to determine hepatoblastoma rates by age and sex in Taiwan.
Purpose of the Study:
- To investigate the incidence rates of hepatoblastoma in Taiwan.
- To analyze age- and sex-specific incidence patterns.
- To identify trends in hepatoblastoma occurrence.
Main Methods:
- Utilized data from the Taiwan Cancer Registry (1995-2012).
- Calculated age-standardized incidence rates (ASIRs) using International Agency for Research on Cancer methods.
- Analyzed incidence by age groups and sex, including standardized incidence rate ratios (SIRRs).
Main Results:
- 211 hepatoblastoma cases were identified from 1995-2012; overall ASIR was 0.76 per million person-years.
- Hepatoblastoma predominantly affected children (87.2%), peaking in the 0-4 age group (ASIR 7.3 per million person-years).
- Incidence significantly increased in children (7.4% annually) and boys (6.5% annually) during the study period.
Conclusions:
- Adult hepatoblastoma (≥15 years) is rare (27 cases), necessitating molecular studies for understanding.
- The rising incidence in boys may be linked to increased survival rates of premature infants.
- Further investigation is warranted to explore these associations.
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