Air pollution and emergency department visits for respiratory diseases: A multi-city case crossover study

Increasing evidence suggests that ambient air pollution is a major risk factor for both acute and chronic respiratory disease exacerbations and emergencies. The objective of this study was to determine the association between ambient air pollutants and emergency department (ED) visits for respiratory conditions in nine districts across the province of Ontario in Canada. Health, air pollutant (PM_2.5, NO₂, O₃, and SO₂), and meteorological data were retrieved from April 2004 to December 2011. Respiratory diseases were categorized as: chronic obstructive pulmonary disease (COPD, including bronchiectasis) and acute upper respiratory diseases. A case-crossover design was used to test the associations between ED visits and ambient air pollutants, stratified by sex and season. For COPD among males, positive results were observed for NO₂ with lags of 3-6 days, for PM_2.5 with lags 1-8, and for SO₂ with lags of 4-8 days. For COPD among females, positive results were observed for O₃ with lags 2-4 days, and for SO₂ among lags of 3-6 days. For upper respiratory disease emergencies among males, positive results were observed for NO₂ (lags 5-8 days), for O₃, (lags 0-6 days), PM_2.5 (all lags), and SO₂ (lag 8), and among females, positive results were observed for NO₂ for lag 8 days, for O₃, PM_2.5 among all lags. Our study provides evidence of the associations between short-term exposure to air pollution and increased risk of ED visits for upper and lower respiratory diseases in an environment where air pollutant concentrations are relatively low.