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Updated: Feb 14, 2026
Author Spotlight: A Stable Phantom Material for Optical and Acoustic Imaging
Published on: June 16, 2023
[Development of a Striatal and Skull Phantom for Quantitative 123I-FP-CIT SPECT]
Masanobu Ishiguro1,2, Masaki Uno1, Takuma Miyazaki2
1Section of Radiology, Fujita Health University Hospital.
Background:
123Iodine-labelled N-(3-fluoropropyl) -2β-carbomethoxy-3β-(4-iodophenyl) nortropane (123I-FP-CIT) single photon emission computerized tomography (SPECT) images are used for differential diagnosis such as Parkinson's disease (PD). Specific binding ratio (SBR) is affected by scattering and attenuation in SPECT imaging, because gender and age lead to changes in skull density. It is necessary to clarify and correct the influence of the phantom simulating the the skull.
Purpose:
The purpose of this study was to develop phantoms that can evaluate scattering and attenuation correction.
Methods:
Skull phantoms were prepared based on the measuring the results of the average computed tomography (CT) value, average skull thickness of 12 males and 16 females. 123I-FP-CIT SPECT imaging of striatal phantom was performed with these skull phantoms, which reproduced normal and PD. SPECT images, were reconstructed with scattering and attenuation correction. SBR with partial volume effect corrected (SBRact) and conventional SBR (SBRBolt) were measured and compared.
Results:
The striatum and the skull phantoms along with 123I-FP-CIT were able to reproduce the normal accumulation and disease state of PD and further those reproduced the influence of skull density on SPECT imaging. The error rate with the true SBR, SBRact was much smaller than SBRBolt.
Conclusion:
The effect on SBR could be corrected by scattering and attenuation correction even if the skull density changes with 123I-FP-CIT on SPECT imaging. The combination of triple energy window method and CT-attenuation correction method would be the best correction method for SBRact.
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