Erythrocyte Glucose-6-Phosphate Dehydrogenase Level in Type 2 Diabetes Male

The patient with diabetes mellitus (DM) and its complication is increasing in our country and all over the world. There is also significant increase in the prevalence of erythrocyte glucose-6-phosphate dehydrogenase (eG6PD) deficiency in the men with longer duration of diabetes mellitus. To assess the eG6PD in type 2 diabetes male subjects to observe their enzyme status. This cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from January 2011 to December 2011. Sixty male subjects with type 2 diabetes mellitus were selected with the age ranging from 40 to 60 years. Out of diabetic subjects, 30 (thirty) were with controlled (B1) and other 30 (thirty) with uncontrolled (B2) type 2 diabetes mellitus were selected from Outpatient Department of BIRDEM Hospital by random basis. And 30 age-matched, healthy non-diabetic male subjects were considered as control group for comparison. Erythrocyte G6PD level was measured by spectrophotometric method. Fasting Blood Glucose (FBG), HbA1c were measured by standard laboratory techniques in the laboratory of BIRDEM and Armed Forces Institute of Pathology (AFIP), Dhaka Cantonment, Dhaka. For statistical analysis unpaired Student's 't' test was performed. The result was expressed as Mean±SD among the groups. In this study, eG6PD level was significantly lower in both the study groups. This study concludes that eG6PD level decreases in male with diabetes mellitus.