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Related Experiment Video

Updated: Feb 14, 2026

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Controlling striatal function via anterior frontal cortex stimulation.

Mieke van Holstein1,2, Monja I Froböse3, Jacinta O'Shea3,4

  • 1Radboud University, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands. miekevanholstein@gmail.com.

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|February 21, 2018
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Summary
This summary is machine-generated.

Transcranial magnetic stimulation (TMS) over the anterior prefrontal cortex (aPFC) reduced reward processing in the striatum. This suggests frontal regions causally control striatal goal processing, impacting motivational information transfer.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Corticostriatal circuits differentially process motivational, cognitive, and action goals.
  • Understanding causal relationships between cortical and striatal activity is crucial for goal-directed behavior.

Purpose of the Study:

  • To investigate the causal influence of frontal cortical regions on striatal processing.
  • To determine if transcranial magnetic stimulation (TMS) over specific frontal areas affects goal-related striatal activity.

Main Methods:

  • Employed a within-subject crossover design with 27 participants.
  • Applied continuous theta burst stimulation over anterior prefrontal cortex (aPFC), dorsolateral prefrontal cortex, or premotor cortex.
  • Utilized task-related functional magnetic resonance imaging (fMRI) to assess striatal processing before and after TMS, alongside reward, cognitive, and action switching tasks.

Main Results:

  • Anterior prefrontal cortex (aPFC) stimulation showed a trend towards decreased reward-related processing in the caudate nucleus.
  • Follow-up analysis indicated aPFC stimulation reduced processing in the putamen.
  • These effects suggest modulation of motivational information transfer within cortico-striatal circuitry.

Conclusions:

  • Anterior prefrontal cortex (aPFC) plays a causal role in modulating motivational information processing within the striatum.
  • Findings support the causal control of distinct frontal regions over specific corticostriatal circuits for goal-directed behaviors.
  • This research advances our understanding of the neural mechanisms underlying goal pursuit.