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Updated: Feb 14, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
Published on: December 27, 2010
Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference
Laura J Corbin1,2, Vanessa Y Tan1,2, David A Hughes1,2
1MRC Integrative Epidemiology Unit at University of Bristol, Bristol, BS8 2BN, UK.
Abstract:
Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks that allow causal inference. Here, we discuss the characteristics of Recall-by-Genotype (RbG) as a study design aimed at addressing both these needs. We describe two broad scenarios for the application of RbG: studies using single variants and those using multiple variants. We consider the efficacy and practicality of the RbG approach, provide a catalogue of UK-based resources for such studies and present an online RbG study planner.
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