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Coenzyme Q10 Supplementation in Aging and Disease.
Juan D Hernández-Camacho1, Michel Bernier2, Guillermo López-Lluch1
1Centro Andaluz de Biología del Desarrollo and CIBERER, Instituto de Salud Carlos III, Universidad Pablo de Olavide-CSIC-JA, Sevilla, Spain.
Frontiers in Physiology
|February 21, 2018
Summary
Coenzyme Q10 (CoQ10) supplementation shows promise for improving mitochondrial function and alleviating aging symptoms. Further research is needed to confirm its benefits for various chronic diseases.
Area of Science:
- Biochemistry
- Cellular Biology
- Nutritional Science
Background:
- Coenzyme Q (CoQ) is vital for mitochondrial electron transport and acts as an antioxidant.
- Endogenous CoQ production involves a complex mitochondrial pathway; defects can lead to deficiency and oxidative stress.
- Lower CoQ10 levels are observed in aging and chronic diseases, suggesting supplementation benefits.
Purpose of the Study:
- To review CoQ10 biosynthesis and primary deficiency syndromes.
- To analyze clinical trial data on CoQ10 supplementation.
- To evaluate the potential of CoQ10 in mitigating aging and disease symptoms.
Main Methods:
- Literature review of CoQ10 biosynthesis.
- Analysis of published clinical trial results on CoQ10 supplementation.
- Synthesis of evidence regarding CoQ10's impact on bioenergetics and oxidative stress.
Main Results:
- CoQ10 supplementation positively impacts mitochondrial deficiency syndrome and aging symptoms, primarily through bioenergetic improvements.
- The antioxidant properties of CoQ10 help alleviate cardiovascular disease and inflammation.
- Evidence suggests potential benefits for aging and mitochondrial disorders, but more research is required.
Conclusions:
- CoQ10 supplementation shows efficacy in addressing mitochondrial dysfunction and aging-related symptoms.
- Its antioxidant effects are beneficial for cardiovascular health and inflammation.
- Further large-scale, long-term clinical trials are necessary to establish CoQ10's role in metabolic syndrome, diabetes, neurodegenerative diseases, kidney disease, and fertility.
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