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Updated: Feb 14, 2026

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT
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Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Published on: May 2, 2012

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Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential

David R Sweet1,2, Liyan Fan1,2, Paishiun N Hsieh1,2

  • 1Case Cardiovascular Research Institute, Case Western Reserve University, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.

Frontiers in Cardiovascular Medicine
|February 21, 2018
PubMed

Insights

Krüppel-like factors (KLFs) regulate vascular inflammation, impacting cardiovascular diseases like atherosclerosis and stroke. Understanding KLF networks offers new therapeutic targets for vascular conditions.

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Molecular Biology

Background:

  • Vascular inflammation, involving immune cells and vessel wall components, drives pathological remodeling.
  • This inflammation contributes to atherothrombotic diseases, including myocardial infarction, stroke, and critical limb ischemia.
  • Signaling pathways in vascular inflammation dictate transcriptional changes affecting cellular functions.

Purpose of the Study:

  • To review the role of Krüppel-like factors (KLFs) in vascular inflammation.
  • To explore how KLFs coordinate protective and detrimental responses in vascular inflammation.
  • To discuss the potential of targeting KLFs for cardiovascular disease therapies.

Main Methods:

  • This review synthesizes existing literature on KLFs in vascular inflammation.
  • It examines the functions of KLFs in both homeostatic and diseased vascular states.
  • The review focuses on transcriptional networks regulated by KLFs.

Main Results:

  • KLFs are central transcription factors regulating vascular biology.
  • KLFs exhibit diverse functions in cells involved in vascular inflammation.
  • Understanding KLF networks is crucial for elucidating disease pathogenesis.

Conclusions:

  • KLFs play a critical role in orchestrating vascular inflammation.
  • Targeting KLFs presents a promising avenue for future cardiovascular disease treatments.
  • Further research into KLF transcriptional networks will advance understanding and therapy for vascular diseases.

Keywords:
Krüppel-like factorKrüppel-like transcription factorsatherosclerosisendothelial cellsmacrophagesvascular inflammationvascular smooth muscle cells

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