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Updated: Feb 14, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Varicocelectomy with primary gubernaculum veins closure: A randomised clinical trial
F Allameh1, A Hasanzadeh Haddad2, A Abedi2
1Clinical Research Development Unit, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Microsurgical inguinal varicocelectomy with testicular delivery significantly reduces varicocele recurrence and improves sperm motility. This technique offers a safe and effective approach for managing varicoceles and enhancing male fertility.
Area of Science:
- Urology
- Andrology
- Reproductive Medicine
Background:
- Varicocele is a common cause of male infertility.
- Microsurgical inguinal varicocelectomy is a standard treatment.
- The role of testicular delivery in improving outcomes is debated.
Purpose of the Study:
- To compare microsurgical inguinal varicocelectomy with and without testicular delivery.
- To evaluate the impact on semen parameters and recurrence rates.
- To assess post-operative complications.
Main Methods:
- Randomized controlled trial with 416 patients.
- Grade III varicocele patients were divided into two groups.
- Semen analysis performed pre- and post-surgery (6 months).
Main Results:
- Testicular delivery group had significantly lower recurrence rates (1.5% vs 6.5%).
- Both groups showed improved sperm parameters post-surgery.
- Sperm motility showed a significant improvement in the testicular delivery group (p=0.05).
Conclusions:
- Microsurgical varicocelectomy with testicular delivery is safe and effective.
- This technique reduces recurrence and improves sperm motility.
- It offers potential advantages over conventional methods for varicocele treatment.
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