Related Experiment Video

Updated: Feb 14, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.9K

Del Nido cardioplegia for minimally invasive aortic valve replacement

Michael S Koeckert1, Deane E Smith1, Patrick F Vining1

  • 1Department of Cardiothoracic Surgery, NYU School of Medicine, NYU Langone Health, New York, New York.

Journal of Cardiac Surgery
|February 21, 2018
PubMed
Abstract

Insights

Del Nido cardioplegia (DNC) reduced re-dosing and retrograde delivery needs during minimally invasive aortic valve replacement (MIAVR). Patient safety was maintained in this low-risk group.

Area of Science:

  • Cardiovascular Surgery
  • Cardiac Anesthesia
  • Minimally Invasive Cardiac Surgery

Background:

  • Minimally invasive aortic valve replacement (MIAVR) is an evolving surgical technique.
  • The choice of cardioplegia solution can impact surgical efficiency and patient outcomes.
  • Del Nido Cardioplegia (DNC) is a crystalloid:blood mixture with potential benefits in cardiac procedures.

Purpose of the Study:

  • To evaluate the impact and safety of Del Nido Cardioplegia (DNC) compared to standard Buckberg-based cardioplegia (WBC) in patients undergoing MIAVR.
  • To assess differences in cardioplegia administration, surgical times, and clinical outcomes between the two cardioplegia strategies.

Main Methods:

  • Retrospective analysis of isolated MIAVR procedures from 5/2013-6/2015.
  • Patients were divided into DNC and WBC cohorts, with one-to-one propensity score matching based on risk factors.
  • Outcomes were compared using chi-square and non-parametric statistical methods.

Main Results:

  • Del Nido Cardioplegia (DNC) was associated with significantly reduced re-dosing (8.5% vs 61.0%, P < 0.001) and lower total cardioplegia volume (1290 mL vs 2284 mL, P < 0.001).
  • Antegrade cardioplegia delivery was more frequent with DNC (89.8% vs 33.9%, P < 0.001).
  • No significant differences were observed in bypass/cross-clamp times, postoperative hematocrit, transfusion needs, inotropic support, ICU/hospital length of stay, or mortality.

Conclusions:

  • Del Nido Cardioplegia (DNC) effectively minimized the need for re-dosing and retrograde delivery during MIAVR.
  • The use of DNC in this low-risk MIAVR patient cohort did not compromise patient safety.
  • DNC represents a viable alternative cardioplegia strategy for selected MIAVR procedures.
Keywords:
aortic valve replacementcardioplegiaminimally invasive

More Related Videos

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.8K
Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement08:50

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

12.3K

Related Concept Videos

Gradient and Del Operator01:14

Gradient and Del Operator

In mathematics and physics, the gradient and del operator are fundamental concepts used to describe the behavior of functions and fields in space. The gradient is a mathematical operator that gives both the magnitude and direction of the maximum spatial rate of change. Consider a person standing on a mountain. The slope of the mountain at any given point is not defined unless it is quantified in a particular direction. For this reason, a "directional derivative" is defined, which is a vector...
4.5K
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
12.4K
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
1.2K
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
594
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
712
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
671