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Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
Published on: September 6, 2024
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Self-Assembled Peptide-Based Nanomaterials for Biomedical Imaging and Therapy
Guo-Bin Qi1, Yu-Juan Gao1, Lei Wang1
1CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
Advanced Materials (Deerfield Beach, Fla.)
|February 21, 2018
Summary
This review summarizes peptide-based nanomaterials, detailing their self-assembly, biomedical uses, and clinical translation. It highlights the advantages of in vivo construction for nanomedicine applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Clinical Translation
Background:
- Peptide-based materials are crucial biomaterials with diverse structures and functions.
- Self-assembly strategies enable the creation of stable, multivalent peptide-based nanomaterials.
- Peptide biomaterials are increasingly used in clinical applications, yet a comprehensive review is lacking.
Purpose of the Study:
- To systematically review recent advancements in peptide-based materials.
- To cover fundamental research, self-assembly, and clinical applications.
- To bridge the gap between research and clinical translation of peptide nanomaterials.
Main Methods:
- Systematic review of literature on peptide-based materials.
- Presentation of ex situ and in situ constructed nanomaterials.
- Emphasis on intelligent in situ construction strategies for in vivo applications.
Main Results:
- Detailed summary of molecular building blocks, self-assembly forces, and applications.
- Examples of both ex situ and in situ constructed peptide nanomaterials.
- Highlighting the benefits of in vivo self-assembly for nanomedicine.
Conclusions:
- Self-assembled peptide nanostructures are vital for nanomedicine.
- In situ construction offers advantages in nanostructure modulation and biomedical effects.
- This review facilitates further understanding and clinical translation of these nanosystems.
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