Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Monohybrid Crosses01:20

Monohybrid Crosses

239.8K
Overview
239.8K
Dihybrid Crosses01:18

Dihybrid Crosses

81.5K
Overview
81.5K
Crossing Over01:34

Crossing Over

172.3K
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
172.3K
Parental Care00:55

Parental Care

12.8K
Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
12.8K
Parenting Styles01:27

Parenting Styles

706
Diana Baumrind's four parenting styles — authoritarian, authoritative, neglectful, and permissive — each influence children's socio-emotional development differently.
Authoritarian Parenting
This style is strict and controlling, with little room for open dialogue. Authoritarian parents demand obedience and often enforce rules with minimal warmth. Children raised this way may lack social skills and initiative, usually comparing themselves to others unfavorably.
Authoritative...
706
Relationship with Parents: Attachment01:28

Relationship with Parents: Attachment

272
Parent-child interactions lay the foundation for how we understand relationships throughout life. These interactions are not uniform across families; instead, they are shaped by a range of environmental, emotional, and behavioral factors unique to each caregiver-child dynamic. Social psychologists study these early relationships to understand how patterns formed in infancy influence social functioning and interpersonal behavior in adulthood.Attachment Theory and Early Relational ModelsJohn...
272

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular genetic influences on sustained attention and executive processes and their links with psychopathology in the AFFECT study.

Molecular psychiatry·2026
Same author

Indoor Radon Concentrations and Hematologic Traits in the Women's Health Initiative.

Epidemiology (Cambridge, Mass.)·2026
Same author

SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity.

Nature communications·2026
Same author

Higher eQTL power reveals signals that boost GWAS colocalization.

American journal of human genetics·2026
Same author

Multi-tissue transcriptome-wide association study identifies 29 risk genes associated with attention-deficit/hyperactivity disorder.

medRxiv : the preprint server for health sciences·2026
Same author

Life-course Psychosocial Adversity and Biological Aging in the Hispanic Community Health Study / Study of Latinos: A Life-course Model Analysis.

Research square·2026

Related Experiment Video

Updated: Feb 14, 2026

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
11:10

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages

Published on: August 11, 2014

13.2K

Powerful and robust cross-phenotype association test for case-parent trios.

S Taylor Fischer1, Yunxuan Jiang2, K Alaine Broadaway1

  • 1Department of Human Genetics and Center for Computational and Quantitative Genetics, Emory University, Atlanta, Georgia, United States of America.

Genetic Epidemiology
|February 21, 2018
PubMed
Summary

This study introduces a new gene-based association test for multiple phenotypes in family studies. The method enhances statistical power for identifying pleiotropic genes, improving genetic discovery in complex diseases.

Keywords:
case-parent trio designgenetic association testingpleiotropy

More Related Videos

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes
18:38

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 25, 2013

12.5K
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.8K

Related Experiment Videos

Last Updated: Feb 14, 2026

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
11:10

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages

Published on: August 11, 2014

13.2K
Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes
18:38

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 25, 2013

12.5K
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.8K

Area of Science:

  • Genetics
  • Statistical Genetics
  • Bioinformatics

Background:

  • Increasing interest in identifying genes influencing multiple phenotypes (pleiotropy).
  • Existing cross-phenotype association tests often lack applicability to family-based designs.
  • Univariate analysis of individual phenotypes can be underpowered and miss joint effects.

Purpose of the Study:

  • To develop a robust gene-based association test for multiple phenotypes in case-parent trio studies.
  • To provide a statistically powerful alternative to univariate testing for pleiotropic gene discovery.
  • To address limitations of existing methods in family-based genetic association studies.

Main Methods:

  • Utilized the kernel distance covariance (KDC) method.
  • Constructed similarity matrices for multiple phenotypes and genetic variants within genes.
  • Tested dependency between similarity matrices for gene-based association.
  • Method is robust to population stratification and applicable to common/rare variants.

Main Results:

  • Simulation studies demonstrated substantially higher power compared to standard univariate testing.
  • Application to the Genetics of Kidneys in Diabetes (GoKinD) study identified a genome-wide significant gene.
  • The identified gene showed cross-phenotype effects missed by univariate approaches.

Conclusions:

  • The proposed gene-based association test is effective and powerful for detecting pleiotropic genes in family studies.
  • This method offers a valuable tool for genetic discovery in complex diseases using family data.
  • The approach successfully identified novel genetic associations in the GoKinD dataset.