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Updated: Feb 14, 2026
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Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
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Brain Quantitative MRI Metrics in Astronauts as a Unique Professional Group
Khader M Hasan1, Benson Mwangi2, Zafer Keser3
1Medical School, Department of Diagnostic and Interventional Imaging, The University of Texas Health Science Center, Houston, TX.
Summary
Quantitative magnetic resonance imaging revealed structural neuroplasticity in astronauts, suggesting the brain can adapt to space flight. This study highlights brain changes and potential compensatory mechanisms in space travelers.
Area of Science:
- Neuroscience
- Space Medicine
- Medical Imaging
Background:
- International Space Station (ISS) Program monitors astronaut health.
- Long-duration space flight effects on the central nervous system (CNS) are of interest.
- Visual impairment in astronauts prompts further CNS investigation.
Purpose of the Study:
- Demonstrate the utility of multimodal quantitative magnetic resonance imaging (qMRI).
- Examine structural attributes of CNS compartments in astronauts.
- Utilize diffusion tensor imaging (DTI)-based customized brain templates.
Main Methods:
- Retrospective analysis of 10 healthy astronauts (45-55 years).
- Subjects had prior space flights (median 110 days).
- Employed multimodal quantitative structural imaging.
Main Results:
- CNS features generally align with normative data.
- Observed statistically significant positive features indicating neuroplasticity.
- Findings suggest compensatory neurogenesis counteracting age-related volume loss.
Conclusions:
- qMRI toolset shows potential for characterizing unique professional groups.
- This approach can aid future prospective studies on long-term exposure effects on CNS.
- Exploratory report demonstrates a novel surveillance capability for astronaut CNS health.
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