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The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation
Published on: August 15, 2018
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Thyroid function in asphyxiated newborns who received hypothermia therapy.
Akira Kobayashi1,2, Touhei Usuda1, Masaki Wada3
1General Center for Perinatal, Maternal and Neonatal Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan.
Summary
Thyroid hormone levels (free triiodothyronine and free thyroxine) are transiently low in asphyxiated newborns treated with hypothermia. Lower levels at 72-96 hours may predict brain injury.
Area of Science:
- Neonatalogy
- Pediatric Endocrinology
- Neuroscience
Background:
- Thyroid function in newborns undergoing hypothermia therapy for asphyxia is not well understood.
- The relationship between thyroid function and neurological outcomes in these infants requires further investigation.
Purpose of the Study:
- To prospectively assess thyroid function in asphyxiated newborns receiving hypothermia therapy.
- To determine if thyroid hormone levels correlate with neurological injury.
Main Methods:
- Prospective study of 12 asphyxiated newborns treated with hypothermia.
- Measured serum thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) at multiple time points.
- Compared thyroid function between infants with and without brain injury on MRI.
Main Results:
- All newborns had normal serum TSH levels.
- Serum FT3 and FT4 levels were low at 24, 72, and 96 hours, normalizing by discharge.
- Infants with brain injury had significantly lower FT3 at 96 hours and FT4 at 72 and 96 hours compared to those without injury.
Conclusions:
- Asphyxiated newborns treated with hypothermia experience transiently low thyroid hormone levels (FT3 and FT4) between 24-96 hours post-birth.
- Serum FT3 and FT4 levels at 72-96 hours may serve as predictors of brain injury in this population.
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