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Sex hormone-binding globulin levels during the first trimester may predict gestational diabetes mellitus development
Tong Zhang1, Tao Du2, Wangen Li2
1Department of Endocrinology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, PR China.
Aim:
To investigate the association of sex hormone-binding globulin (SHBG) levels of early pregnancy with gestational diabetes mellitus (GDM) development.
Methods:
A total of 443 pregnant women during the first trimester (<12 weeks) were enrolled. SHBG levels were measured.
Results:
SHBG level was lower in women with GDM than in women without GDM (93.9 ± 34.4 nmol/l vs 128.1 ± 60.3 nmol/l; p = 0.001). Among the four quartiles (Q1-Q4) according to SHBG levels, GDM incidences were 17.5, 27.8, 5.1 and 2.6%, respectively. No differences were found between Q1 and Q2, and Q3 and Q4. The risk of developing GDM among women in Q1 + Q2 compared with Q3 + Q4 was 5.7.
Conclusion:
Decreased SHBG concentrations during the first trimester may predict GDM development.
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