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Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Related Experiment Video

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Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
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[Alzheimer's disease].

O A Kicherova1, L I Reikhert1

  • 1Tyumen State Medical University, Tyumen, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|February 21, 2018
PubMed
Summary

Alzheimer's disease (AD) is a leading cause of dementia, characterized by memory loss and behavioral issues. Early diagnosis and understanding its causes, including genetics and environmental factors, are crucial for managing this neurodegenerative condition.

Keywords:
Alzheimer's diseasecerebral amyloidosisdementianeurodegeneration

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Area of Science:

  • Neurology
  • Neuroscience
  • Geriatrics

Background:

  • Alzheimer's disease (AD) is the most prevalent cause of dementia in older adults.
  • AD presents with progressive memory loss and behavioral disturbances.
  • Early diagnosis is challenging, often requiring differentiation from other neurodegenerative diseases.

Purpose of the Study:

  • To present clinical diagnostic criteria for Alzheimer's disease.
  • To explore diagnostic potential in the predementia stage using biomarkers.
  • To review current understanding of AD etiology, pathogenesis, genetics, and environmental influences.

Main Methods:

  • Review of clinical diagnostic criteria for AD.
  • Evaluation of diagnostic possibilities in the predementia stage.
  • Analysis of etiological, pathogenetic, genetic, and environmental factors in AD.

Main Results:

  • Clinical criteria for AD diagnosis are presented.
  • Diagnostic approaches for the predementia stage using biomarkers are considered.
  • Etiology, pathogenesis, genetics, and environmental contributions to AD are discussed.

Conclusions:

  • Accurate diagnosis of Alzheimer's disease is essential for effective patient management.
  • Biomarkers hold promise for earlier AD detection, even in predementia stages.
  • A comprehensive understanding of AD's multifactorial origins is vital for future research and treatment development.