Related Experiment Video
Updated: Feb 14, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
Oral Immunotherapy With Egg and Milk: Changes in Peripheral Serum Cytokines Are Not Predictive Factors for Severe
E García-Lirio1, C Gonzalez Diaz2, A Gonzalez Hermosa2
1Servicio de Alergología, Hospital Universitario Cruces, Barakaldo, Spain.
Background:
Oral immunotherapy (OIT) is a new approach in patients with food allergy. Various immunological mechanisms underlie the reversal of food allergy. In this paper, we study possible changes in peripheral cytokine patterns during OIT.
Methods:
Determinations of cytokines in peripheral blood were made in children who had milk or egg allergy and who received OIT. The determinations were made before and after OIT, and again following a final repeat oral challenge a month after a diet excluding the culprit food.
Results:
No significant changes were registered in the cytokines studied (IL-2, IL-4, IL-6, IL-10, IL-12, IL-17, IFNγ, and TNF) at any of the 3 time points. Similarly, no differences in cytokine pattern were observed between children who had presented anaphylaxis during OIT and those who overcame or did not overcome the final oral challenge.
Discussion:
Peripheral cytokines do not undergo significant changes during the OIT process. They are not predictors of serious adverse reactions or the final result of the OIT.
More Related Videos
Related Concept Videos
Predicting Reaction Outcomes
Data Reporting and Recording
Tumor Immunotherapy
Factors Influencing the Rate of Chemical Reactions
Concentration and Pressure:
The more particles present within a given space, the more likely those particles are to bump into one another....
Predicting Molecular Geometry
Reaction Mechanisms
For instance, the decomposition of ozone appears to follow a mechanism with two steps:

