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Updated: Feb 14, 2026
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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
Published on: June 9, 2017
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Endothelial cell protein C receptor-dependent signaling
Usha R Pendurthi1, L Vijaya Mohan Rao
1Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
Current Opinion in Hematology
|February 21, 2018
Summary
Endothelial cell protein C receptor (EPCR) mediates cytoprotective signaling pathways. Recent findings reveal EPCR
Area of Science:
- Molecular Biology
- Cellular Signaling
- Hematology
Background:
- Endothelial cell protein C receptor (EPCR) is a key component of the protein C anticoagulant system.
- EPCR plays a critical role in activated protein C (APC)-mediated cytoprotective signaling.
Purpose of the Study:
- To outline the mechanisms of EPCR-dependent cell signaling.
- To discuss recent findings in EPCR-mediated signaling.
Main Methods:
- Review of recent scientific literature.
- Analysis of EPCR's role in various signaling pathways.
Main Results:
- EPCR mediates biased cytoprotective signaling through protease-activated receptor 1 (PAR1) cleavage.
- Factor VIIa binding to EPCR also induces cytoprotective signaling.
- EPCR serves as a marker for hematopoietic stem cells and is implicated in malaria, immune functions, and cancer.
Conclusions:
- EPCR contributes mechanistically to PAR1-mediated biased signaling.
- EPCR's diverse ligand binding suggests broad roles in biological functions.
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