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Expression of miR-146a-5p in patients with intracranial aneurysms and its association with prognosis

H-L Zhang1, L Li, C-J Cheng

  • 1Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. sunxiaochuandn@163.com.

European Review for Medical and Pharmacological Sciences
|February 21, 2018
PubMed
Abstract

Insights

Higher miR-146a-5p expression in plasma is associated with intracranial aneurysms (IAs). This microRNA may serve as a prognostic biomarker for predicting outcomes in IA patients.

Area of Science:

  • Biomarkers
  • Molecular Biology
  • Neuroscience

Background:

  • Intracranial aneurysms (IAs) are a significant cause of cerebrovascular disease.
  • Identifying reliable biomarkers for IA prognosis is crucial for patient management.

Purpose of the Study:

  • To investigate the association between miR-146a-5p expression and intracranial aneurysms (IAs).
  • To evaluate miR-146a-5p as a potential prognostic biomarker in IA patients.

Main Methods:

  • Quantitative Real-time polymerase chain reaction (qRT-PCR) was used to measure miR-146a-5p expression in plasma samples.
  • Plasma samples were collected from 72 IA patients and 40 healthy controls.
  • Statistical analyses, including Cox proportional hazards models, were performed.

Main Results:

  • Higher miR-146a-5p expression was observed in IA patients compared to healthy controls.
  • Elevated miR-146a-5p levels correlated with aneurysm rupture and Hunt-Hess grade.
  • Higher miR-146a-5p expression was an independent predictor of shorter overall survival in IA patients.

Conclusions:

  • MiR-146a-5p may serve as a valuable biomarker for predicting prognosis in patients with intracranial aneurysms.
  • Further research is warranted to explore the therapeutic potential of targeting miR-146a-5p.

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