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Updated: Feb 14, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Enantioselective Copper-Catalyzed Methylboration of Alkenes
Bin Chen1,2,3, Peng Cao3, Yang Liao1
1Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China and University of Chinese Academy of Sciences , Beijing 10049, People's Republic of China.
Abstract:
An enantioselective Cu-catalyzed borylative cross-coupling reaction of alkenes, bis(pinacolato)diboron (B2(pin)2), and methyl iodide is reported. Alkenes including styrenes, β-substituted styrenes, and challenging aliphatic olefins were smoothly transferred to the desired methylboration products with excellent diastereoselectivities (dr up to >99:1) and enantioselectivities (er up to 99:1). The utility of this process was demonstrated by the synthesis of naproxen and formal synthesis of two natural products.
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