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Expression Profiles of Six Atherosclerosis-Associated microRNAs That Cluster in Patients with Hyperhomocysteinemia: A

Kejian Liu1,2, Saiyare Xuekelati3, Kang Zhou2

  • 11 Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China .

DNA and Cell Biology
|February 21, 2018
PubMed

Insights

Plasma microRNAs (miRNAs) can predict atherosclerosis in hyperhomocysteinemia patients. Specifically, miR-217 shows diagnostic value for atherosclerosis, aiding in predicting disease progression.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Hyperhomocysteinemia (Hhcy) is linked to atherosclerosis.
  • Plasma microRNAs (miRNAs) are potential biomarkers for various diseases.
  • Specific miRNAs regulate genes involved in atherosclerosis development.

Purpose of the Study:

  • To investigate if plasma atherosclerosis-associated miRNAs can predict atherosclerosis in Hhcy patients.
  • To identify specific miRNAs with diagnostic potential for Hhcy-complicated atherosclerosis.

Main Methods:

  • Selected six plasma miRNAs (miR-145, miR-155, miR-222, miR-133, miR-217, miR-30) known to be involved in atherosclerosis.
  • Measured miRNA expression levels in plasma from Hhcy patients with and without atherosclerosis.
  • Correlated miRNA expression with homocysteine (Hcy) and lipid parameters.

Main Results:

  • Significant differential expression of five miRNAs (upregulation of miR-133, miR-217; downregulation of miR-145, miR-155, miR-222) was observed.
  • miR-217 was significantly upregulated in Hhcy + Atherosclerosis (ATH) groups compared to controls.
  • miR-217 showed a negative correlation with Hcy and triglycerides and specific expression patterns in ATH patients.

Conclusions:

  • Plasma miR-217 expression is a potential diagnostic biomarker for atherosclerosis in Hhcy patients.
  • miR-217 may effectively predict the progression of atherosclerosis in individuals with Hhcy.
  • Targeting miR-217 could offer therapeutic strategies for Hhcy-associated atherosclerosis.

Keywords:
atherosclerosisclusterhyperhomocysteinemiamicroRNAs

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