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Updated: Feb 14, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

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Comparison of Methicillin-resistant Versus Susceptible Staphylococcus aureus Pediatric Osteomyelitis

William T Davis1, Shawn R Gilbert1,2

  • 1School of Medicine, University of Alabama at Birmingham.

Journal of Pediatric Orthopedics
|February 21, 2018
PubMed
Abstract

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) pediatric osteomyelitis is more common in the South and Midwest, and among Black patients. MRSA infections lead to more surgeries, complications, and longer hospital stays compared to MSSA.

Area of Science:

  • Pediatric infectious diseases
  • Orthopedic surgery
  • Public health epidemiology

Background:

  • Pediatric osteomyelitis incidence is rising, with methicillin-resistant Staphylococcus aureus (MRSA) infections presenting a more severe clinical course than methicillin-susceptible Staphylococcus aureus (MSSA).
  • National databases remain underutilized for tracking pediatric osteomyelitis trends.

Purpose of the Study:

  • To compare the demographics, clinical course, and outcomes of pediatric osteomyelitis patients with MRSA versus MSSA infections.
  • To identify demographic factors predicting MRSA in pediatric osteomyelitis.
  • To evaluate MRSA as a predictor of clinical outcomes.

Main Methods:

  • Utilized the 2009 and 2012 Healthcare Cost and Utilization Project Kids Inpatient Database.
  • Included discharge records with diagnosis codes for osteomyelitis and S. aureus.
  • Analyzed demographics, surgical interventions, sepsis, thrombophlebitis, length of stay, and total charges.

Main Results:

  • Of 4214 records, 38.3% involved MRSA. MRSA was more prevalent in Southern and Midwestern hospitals, among Medicaid patients, and Black patients.
  • MRSA patients had higher rates of multiple surgeries, severe sepsis, thrombophlebitis, and pulmonary embolism.
  • MRSA patients experienced longer hospital stays and higher total charges, even after controlling for length of stay.

Conclusions:

  • MRSA pediatric osteomyelitis is more prevalent in specific US regions and demographic groups.
  • MRSA infections are associated with increased surgical interventions, a higher complication rate, and prolonged hospitalizations.

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