Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Periprosthetic Supracondylar Femoral Fractures Above a Total Knee Replacement: An Updated Compatibility and Technique Guide for Fixation With a Retrograde Intramedullary Nail: Erratum.

Journal of orthopaedic trauma·2025

Same author

The First Case of Bridge-Enhanced Anterior Cruciate Ligament (ACL) Repair (BEAR) Procedure in Mississippi.

Cureus·2023

Same author

Efficient trapping and destruction of SARS-CoV-2 using PECO-assisted Molekule air purifiers in the laboratory and real-world settings.

Ecotoxicology and environmental safety·2023

Same author

External Validation of the Radiographic Investigation of the Distal Extension of Fractures Into the Articular Surface of the Tibia (RIDEFAST Study).

Journal of orthopaedic trauma·2021

Same author

Reactive Oxygen Species Mediate Activity-Regulated Dendritic Plasticity Through NADPH Oxidase and Aquaporin Regulation.

Frontiers in cellular neuroscience·2021

Same author

Periprosthetic Supracondylar Femoral Fractures Above a Total Knee Replacement: An Updated Compatibility and Technique Guide for Fixation With a Retrograde Intramedullary Nail.

Journal of orthopaedic trauma·2021

Search research articles

Related Experiment Video

Updated: Feb 14, 2026

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner

Published on: June 6, 2025

Patient Mortality in Geriatric Distal Femur Fractures.

Philip Myers¹, Patrick Laboe², Kory J Johnson³

¹OrthoIndy Trauma, St. Vincent Trauma Center, St. Vincent Orthopedics and Spine Center, Indianapolis, IN.

Journal of Orthopaedic Trauma

|February 21, 2018

Summary

This summary is machine-generated.

Elderly patients with distal femur fractures have a 13.4% 1-year mortality rate. Delaying surgery beyond two days increases mortality risk, irrespective of patient health.

More Related Videos

Establishing a Diaphyseal Femur Fracture Model in Mice

Establishing a Diaphyseal Femur Fracture Model in Mice

Published on: December 9, 2022

Transverse Fracture of the Mouse Femur with Stabilizing Pin

Transverse Fracture of the Mouse Femur with Stabilizing Pin

Published on: December 29, 2021

Related Experiment Videos

Last Updated: Feb 14, 2026

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner

Published on: June 6, 2025

Establishing a Diaphyseal Femur Fracture Model in Mice

Establishing a Diaphyseal Femur Fracture Model in Mice

Published on: December 9, 2022

Transverse Fracture of the Mouse Femur with Stabilizing Pin

Transverse Fracture of the Mouse Femur with Stabilizing Pin

Published on: December 29, 2021

Area of Science:

Orthopaedic surgery
Geriatric trauma care
Fracture management

Background:

Distal femur fractures are common in the elderly.
Operative treatment is standard, but mortality risks are significant.
Identifying mortality predictors is crucial for patient outcomes.

Purpose of the Study:

To estimate the 1-year mortality rate in elderly patients undergoing operative treatment for distal femur fractures.
To identify potential risk factors associated with this mortality.

Main Methods:

Retrospective chart review of 283 elderly patients (average age 76) with distal femur fractures.
Data collected from Level 1 and Level 2 trauma centers between 2002 and 2012.
Analysis focused on survival up to 1 year post-surgery.

Main Results:

The 1-year mortality rate was 13.4%.
Delayed surgery (more than 2 days post-injury) was significantly associated with higher mortality at 30 days, 6 months, and 1 year.
Lower Charlson Comorbidity Index scores were observed in survivors compared to non-survivors.

Conclusions:

Elderly patients with distal femur fractures face a substantial 1-year mortality risk.
Timely surgical intervention (within 2 days) is critical for improving survival outcomes.
Surgical timing appears to be a more significant factor than baseline comorbidities for 1-year survival.