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Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis

Sonoko Tasaki1,2, Tamaki Cho1, Jun-Ichi Nagao1

  • 1Section of Infection Biology, Department of Functional Bioscience, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan.

FEMS Yeast Research
|February 21, 2018
PubMed

Insights

Researchers identified key Candida albicans antigens in mycelial membrane proteins. These antigens effectively promote T helper 17 (Th17) cell differentiation, offering a promising avenue for immunotherapy against candidiasis.

Area of Science:

  • Immunology
  • Microbiology
  • Infectious Diseases

Background:

  • Candida albicans is a common fungus causing opportunistic infections.
  • Th17 cells are crucial for immunity against mucosal C. albicans infections.
  • T cell antigens for C. albicans immunotherapy are not well-defined.

Purpose of the Study:

  • Identify effective T cell antigens from C. albicans for immunotherapy.
  • Investigate the role of different C. albicans cell fractions in T cell activation.
  • Evaluate the therapeutic potential of identified antigens in preventing candidiasis.

Main Methods:

  • Fractionation of yeast and mycelial cells of C. albicans (cytosol, membrane, cell wall).
  • Induction of CD4+ T cell differentiation into IL-17A-producing Th17 cells using protein fractions.
  • Adoptive transfer experiments with ex vivo stimulated CD4+ T cells in a mouse model of oral candidiasis.

Main Results:

  • Proteins from the mycelial membrane fraction effectively induced Th17 cell differentiation.
  • Adoptively transferred Th17 cells, differentiated by mycelial membrane proteins, prevented oral candidiasis.
  • Reduced clinical scores and neutrophil counts in infected tissues confirmed the protective effect.

Conclusions:

  • Mycelial membrane proteins of C. albicans contain effective T cell antigens for candidiasis immunotherapy.
  • These findings pave the way for developing novel vaccination strategies against candidiasis.

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