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Evaluation of Respiratory Muscle Activation Using Respiratory Motor Control Assessment RMCA in Individuals with Chronic Spinal Cord Injury
Published on: July 19, 2013
Docosahexaenoic acid improves motor function in the model of spinal cord injury
Igor Manzhulo1, Anna Tyrtyshnaia1, Yuliya Kipryushina2
1National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, 690041, Russia; School of Biomedicine, Far Eastern Federal University, Vladivostok, 690950, Russia.
Abstract:
The present study demonstrates that docosahexaenoic acid (DHA, 22:6n-3) injected subcutaneously leads to recovery of locomotor functions observed within 5 weeks after traumatic spinal cord injury. This activity is confirmed by improving of BBB locomotor rating scale indicators. We assume that this activity is related to (1) enhancement of remyelination process, (2) proliferative activity, (3) antioxidant activity, (4) increase in GFAP staining and (5) enhancement of vimentin expression. In general, the results of the study show that DHA has a complex effect on post-traumatic central nervous system recovery, indicating its high therapeutic potential.
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