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Blood biomarkers in paediatric mild traumatic brain injury: a systematic review

Micaela Lugones1, Georgia Parkin1, Stefan Bjelosevic1

  • 1Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

Neuroscience and Biobehavioral Reviews
|February 21, 2018
PubMed

Insights

Blood biomarkers show promise for diagnosing and monitoring paediatric mild traumatic brain injury (mTBI). GFAP and UCH-L1 are key candidates, but more uniform research is needed for definitive conclusions.

Area of Science:

  • Neurology
  • Biochemistry
  • Pediatrics

Background:

  • Mild traumatic brain injury (mTBI) in children presents diagnostic challenges.
  • Current diagnostic methods for paediatric mTBI can be invasive or lack specificity.
  • There is a need for objective blood-based markers in paediatric mTBI.

Purpose of the Study:

  • To review current research on blood biomarkers for paediatric mTBI.
  • To assess the diagnostic, prognostic, and monitoring potential of these biomarkers.
  • To identify promising biomarkers for future clinical application.

Main Methods:

  • Systematic review adhering to PRISMA guidelines.
  • Searched MEDLINE, PubMed, and EMBASE databases.
  • Included 21 studies evaluating 14 different biomarkers.

Main Results:

  • 81% of studies found significant associations between biomarkers and mTBI.
  • Results are diverse and sometimes conflicting across studies.
  • GFAP shows promise for prognosis/monitoring; UCH-L1 for diagnosis.

Conclusions:

  • Blood biomarkers hold potential for paediatric mTBI management.
  • Heterogeneity in studies hinders definitive conclusions.
  • Standardized research is crucial for validating biomarkers in paediatric mTBI.
Abstract

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