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Related Experiment Video

Updated: Feb 14, 2026

Activating Autophagy by Aerobic Exercise in Mice

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

Lifelong Aerobic Exercise Reduces the Stress Response in Rats.

A Pietrelli¹, M Di Nardo², A Masucci³

¹Department of Basic Sciences Research, School of Health Sciences, University of Business and Social Sciences (UCES), Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Biología Celular y Neurociencia (IBCN), Buenos Aires, Argentina.

|February 21, 2018

Summary

This summary is machine-generated.

Lifelong aerobic exercise (AE) enhances stress resilience in rats by upregulating the hypothalamic-pituitary-adrenal (HPA) axis. This practice mitigates age-related anxiety and emotionality, suggesting AE as a complementary therapy for stress and depression.

Keywords:

HPA axis aging anxiety exercise stress treadmill running

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Area of Science:

Neuroscience
Endocrinology
Exercise Physiology

Background:

The hypothalamic-pituitary-adrenal (HPA) axis response to exercise varies between voluntary and forced models.
Lifelong aerobic exercise (AE) effects on the stress system, particularly with aging, require further investigation.

Purpose of the Study:

To analyze the effects of lifelong aerobic exercise (AE) on the adaptive response of the stress system in aging rats.
To evaluate AE's impact on behavioral, biochemical, and histopathological markers of stress.

Main Methods:

Male Wistar rats were divided into exercise (E) and control (C) groups subjected to chronic AE.
Evaluations were conducted at middle age (8 months) and old age (18 months).
Included behavioral tests, biochemical assays (corticosterone, CRF), and histopathological analysis of adrenal glands.

Main Results:

AE increased adrenal sensitivity, brain corticosterone, and CRF, without affecting adrenal weight or plasma corticosterone.
AE reduced anxiety-related behavior and emotionality, and mitigated age-induced neuroendocrine dysregulation.
Aging led to decreased adrenal sensitivity and neuroendocrine feedback deregulation, which AE counteracted.

Conclusions:

Lifelong AE promotes adaptive responses in the HPA axis, enhancing stress resilience without adverse chronic stress effects.
AE mitigates age-related anxiety and emotionality, suggesting its potential as a complementary therapy for stress and depression.
Compensatory mechanisms, modulated by age, appear to underlie AE's positive impact on stress resilience.