The Effects of Intermittent Whole-Body Hypoxic Preconditioning on Patients with Carotid Artery Stenosis
Huajun Tan1, Hao Lu2, Qian Chen2
1Graduate School of Tianjin Medical University, Tianjin, People's Republic of China; Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, People's Republic of China.
Insights
Intermittent hypoxic preconditioning altered vital signs and blood markers in carotid artery stenosis patients. This intervention showed no new complications or organ damage, suggesting a potentially safe method for managing these patients.
Area of Science:
- Cardiovascular Medicine
- Respiratory Physiology
- Neurosurgery
Background:
- Carotid artery stenosis poses significant risks for stroke.
- Preconditioning strategies are explored to mitigate surgical risks.
- Hypoxic preconditioning is a novel approach to improve patient outcomes.
Purpose of the Study:
- To investigate the effects of intermittent whole-body hypoxic preconditioning.
- To assess its impact on patients diagnosed with carotid artery stenosis.
Main Methods:
- Fifty patients with carotid artery stenosis were randomized into a hypoxic intervention group (HIG) and a control group (CG).
- Both groups underwent a 7-day hypoxic respiration intervention (HIG: 18% O2, CG: 21% O2).
- Vital signs and various blood biomarkers were measured pre- and post-intervention.
Main Results:
- Significant differences in vital signs were observed between HIG and CG during intervention (P < 0.05).
- Postoperative hemoglobin, erythropoietin, HIF-1α, and VEGF increased significantly in HIG (P < 0.05).
- NSE and S100β protein increased postoperatively in CG (P < 0.05), while BDNF and organ function markers remained unchanged in both groups.
Conclusions:
- Intermittent hypoxic preconditioning effectively modifies vital signs and hematologic indexes in carotid artery stenosis patients.
- The intervention did not induce new postoperative complications or organ damage.
- Hypoxic preconditioning presents a potentially safe adjunctive therapy for patients with carotid artery stenosis.
Objective:
To study the effects of intermittent whole-body hypoxic preconditioning on patients with carotid artery stenosis.
Methods:
Fifty patients with carotid artery stenosis were selected and randomly divided into a hypoxic intervention group (HIG) and a control group (CG). Both groups were treated with a hypoxic respiration device for 7 days (HIG: 18% oxygen, CG: 21% oxygen). Venous blood samples were taken preoperatively and postoperatively. The subjects' vital signs were recorded during and after the intervention. After the completion of the trial, the concentrations of hemoglobin, hypoxia inducible factor-1α, erythropoietin, vascular endothelial growth factor, neuron-specific enolase, S100β protein, brain-derived neurotrophic factor, serum aspartate transaminase, serum alanine aminotransferase, serum creatinine, and blood urea nitrogen were measured in the previously selected blood samples.
Results:
During the intervention, the vital signs of the HIG were significantly different from those of the CG (P < 0.05). In the HIG, postoperative concentrations of hemoglobin, erythropoietin, hypoxia inducible factor-1α, and vascular endothelial growth factor were significantly more than the preoperative values (P < 0.05). In the CG, postoperative concentrations of neuron-specific enolase and S100β protein were more than the preoperative values (P < 0.05). The concentrations of brain-derived neurotrophic factor, serum aspartate transaminase, serum alanine aminotransferase, serum creatinine, and blood urea nitrogen showed no significant differences between their preoperative and postoperative values in either the HIG or the CG (P > 0.05).
Conclusions:
Intermittent hypoxic preconditioning can change the vital signs and hematologic indexes of patients with carotid artery stenosis without causing new postoperative complications or organ damage.
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