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Advanced EUS Guided Tissue Acquisition Methods for Pancreatic Cancer
Pujan Kandel1, Michael B Wallace2
1Department of Gastroenterology and Hepatology Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA. kandel.pujan@mayo.edu.
Cancers
|February 22, 2018
Summary
Pancreas cancer diagnosis often occurs late. New needle technologies allow tumor tissue acquisition for personalized treatments, improving precision therapy for patients with unresectable pancreatic cancer.
Area of Science:
- Oncology
- Gastroenterology
- Surgical Pathology
Background:
- Pancreatic cancer has a poor prognosis, with most patients diagnosed at advanced stages.
- Current treatments, including surgery and chemotherapy, offer limited success.
- Endoscopic ultrasound (EUS) is a key imaging tool, but tissue acquisition for biomarker analysis is limited to the 20% of patients who undergo surgery.
Purpose of the Study:
- To review recent advancements in tissue acquisition techniques for pancreatic cancer.
- To highlight the potential of minimally invasive tissue sampling for personalized medicine.
Main Methods:
- Review of current literature on pancreatic cancer diagnosis and treatment.
- Focus on advancements in needle biopsy technologies for obtaining tumor tissue.
- Discussion of molecular profiling techniques applicable to obtained tissue.
Main Results:
- Minimally invasive tissue acquisition is increasingly feasible for pancreatic cancer.
- Tumor tissue enables comprehensive genomic profiling and biomarker development.
- Personalized treatment strategies can be developed using acquired tissue, even for unresectable cases.
Conclusions:
- Advancements in needle technologies are crucial for obtaining tumor tissue in pancreatic cancer.
- Tissue acquisition facilitates personalized medicine approaches, including targeted therapies and precise chemotherapy.
- These methods offer new avenues for improving outcomes in unresectable pancreatic cancer.
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