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Updated: Jul 25, 2026

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
Published on: August 30, 2011
Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex
Lucas S Broster1,2, Juan Li1,3, Benjamin Wagner1
1a Department of Behavioral Science , University of Kentucky College of Medicine , Lexington , KY , USA.
Objective:
Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex.
Method:
Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects.
Results:
Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect.
Conclusion:
Visual cortex may play a role in maintained repetition effects in persons with early AD.
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