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Grey matter volume in healthy and epileptic beagles using voxel-based morphometry - a pilot study
Lisa Frank1, Matthias Lüpke2, Draginja Kostic3
1Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany. Lisa.Frank@tiho-hannover.de.
BMC Veterinary Research
|February 22, 2018
Summary
Subtle grey matter changes occur in epileptic dogs, similar to humans. Voxel-based morphometry (VBM) effectively detects these brain differences in Beagles with idiopathic epilepsy (IE) and structural epilepsy (SE).
Area of Science:
- Veterinary Neurology
- Neuroimaging
- Comparative Medicine
Background:
- Idiopathic epilepsy (IE) is a common chronic neurological disorder in dogs.
- This study investigated subtle grey matter changes in epileptic dogs.
- Magnetic resonance (MR) images of Beagles were used for uniform brain shape analysis.
Purpose of the Study:
- To prove that subtle grey matter changes occur in epileptic dogs.
- To compare local differences in grey matter volume (GMV) between healthy and epileptic Beagles.
- To assess the efficacy of voxel-based morphometry (VBM) in detecting GMV differences.
Main Methods:
- Voxel-based morphometry (VBM) was employed to compare GMV.
- T1W MR images of 5 healthy and 10 epileptic Beagles (5 IE, 5 SE) were analyzed.
- Image processing involved Amira, FSL, and SPM12 for brain extraction, registration, and statistical analysis.
Main Results:
- Epileptic Beagles (IE and SE) showed significantly reduced GMV in the olfactory bulb, cingulate gyrus, hippocampus, and cortex.
- Beagles with IE exhibited decreased GMV in the olfactory bulb, parietal and temporal cortex, hippocampus, and cingulate gyrus.
- Beagles with SE displayed a mild, statistically significant GMV reduction in the temporal lobe.
Conclusions:
- Focal reduction in GMV occurs in epileptic dogs, mirroring findings in epileptic humans.
- VBM analysis is an effective method for detecting GMV differences in dogs with epilepsy.
- Using a single breed (Beagles) enhances the reliability of VBM analysis for epilepsy studies.
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