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PGI2 Is a Novel SGI1-Relative Multidrug-Resistant Genomic Island Characterized in Proteus mirabilis

Chang-Wei Lei1,2, Yan-Peng Chen1,2, Ling-Han Kong1,2

  • 1Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People's Republic of China.

Antimicrobial Agents and Chemotherapy
|February 22, 2018
PubMed

Insights

A novel genomic island, Proteus genomic island 2 (PGI2), was identified in swine-origin Proteus mirabilis. This island carries a multidrug resistance region and can be transferred to other bacteria.

Area of Science:

  • Genomics
  • Microbiology
  • Antimicrobial Resistance

Background:

  • Genomic islands play a crucial role in bacterial evolution and adaptation.
  • Understanding mobile genetic elements like genomic islands is vital for tracking antimicrobial resistance.

Purpose of the Study:

  • To characterize a novel genomic island, Proteus genomic island 2 (PGI2), identified in Proteus mirabilis.
  • To investigate the genetic makeup and transferability of PGI2.

Main Methods:

  • Genomic DNA sequencing and analysis of Proteus mirabilis.
  • Bioinformatic analysis to identify genomic island structure and related elements.
  • Conjugation experiments to assess PGI2 transferability.

Main Results:

  • A novel 61,578-bp genomic island, PGI2, was identified in swine-origin Proteus mirabilis.
  • The PGI2 backbone shares similarities with Salmonella genomic island 1 and Acinetobacter genomic island 1.
  • PGI2 contains a complex class 1 integron with 14 resistance genes, conferring multidrug resistance (MDR).
  • PGI2 was successfully mobilized to Escherichia coli via conjugation.

Conclusions:

  • PGI2 represents a significant mobile genetic element in Proteus mirabilis.
  • The presence of a multidrug resistance region within PGI2 highlights its potential role in spreading antimicrobial resistance.
  • The conjugative transferability of PGI2 suggests its capacity for dissemination among bacterial populations.
Keywords:
Proteus mirabilisgenomic islandintegronsmultidrug resistance

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