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Updated: Feb 14, 2026

The Application of Open Searching-based Approaches for the Identification of Acinetobacter baumannii O-linked Glycopeptides
Published on: November 2, 2021
Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB
Laura Fernández-García1, Felipe Fernandez-Cuenca2,3,4, Lucía Blasco1
1Servicio de Microbiología, Complejo Hospitalario Universitario A Coruña (CHUAC)-Instituto de Investigación Biomédica (INIBIC), A Coruña, Spain.
Abstract:
The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.
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