Related Experiment Video
Updated: Feb 14, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia
Carmen D Herling1, Nima Abedpour2,3, Jonathan Weiss1
1Department of Internal Medicine I, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50937 Cologne, Germany.
Abstract:
Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand the mechanisms that lead to treatment resistance. To this end, we analyzed whole-exome sequencing data of eight chronic lymphocytic leukemia (CLL) patients that developed resistance upon BCL2-inhibition by venetoclax. Here, we report recurrent mutations in BTG1 (2 patients) and homozygous deletions affecting CDKN2A/B (3 patients) that developed during treatment, as well as a mutation in BRAF and a high-level focal amplification of CD274 (PD-L1) that might pinpoint molecular aberrations offering structures for further therapeutic interventions.
More Related Videos
Related Concept Videos
Development of Antibiotic Resistance
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Resistivity
Resistance
Dynamic Equilibrium
Equivalent Resistance

