Related Experiment Video

Updated: Feb 14, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.8K

A multicenter, retrospective analysis of elderly patients with acute myeloid leukemia who were treated with

Jun Ho Yi1, Silvia Park2, Jung Han Kim3

  • 1Division of Hematology-Oncology, Department of Medicine, Chung-Ang University Hospital, Seoul, Korea.

Oncotarget
|February 22, 2018
PubMed

Insights

Decitabine shows promise as a first-line treatment for elderly acute myeloid leukemia (AML) patients in Korea. This study found improved outcomes in Korean AML patients treated with decitabine.

Area of Science:

  • Hematology
  • Oncology
  • Clinical Research

Background:

  • Decitabine is a standard treatment for elderly acute myeloid leukemia (AML).
  • Its efficacy in Asian populations, specifically Koreans, remains under-evaluated.

Purpose of the Study:

  • To assess the clinical outcomes of decitabine treatment in elderly Korean AML patients.
  • To evaluate decitabine as a potential first-line therapy for this demographic.

Main Methods:

  • Retrospective analysis of 80 Korean elderly AML patients treated with decitabine.
  • Data collected included patient age, risk stratification (favorable, intermediate, poor), and overall survival (OS).

Main Results:

  • The median age of patients was 74 years.
  • Patients were stratified into favorable (7.5%), intermediate (60.0%), and poor (31.3%) risk groups.
  • The median overall survival (OS) was 10.2 months (95% CI 5.0-15.4).

Conclusions:

  • Decitabine treatment demonstrated improved clinical outcomes in the studied Korean elderly AML cohort.
  • Decitabine can be considered a viable first-line treatment option for elderly Korean patients with AML.

Keywords:
acute myeloid leukemiadecitabineelderly patients

More Related Videos

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)06:48

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)

Published on: August 1, 2025

549
Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice10:02

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Published on: January 6, 2023

2.5K

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.1K
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
4.4K
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.3K
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
729
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
1.1K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.2K