Related Experiment Video

Updated: Feb 14, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

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Primary Outcomes of Accelerated Epithelium-Off Corneal Cross-Linking in Progressive Keratoconus in Children: A 1-Year

Sherif A Eissa1, Nashwa Badr Eldin1, Ashraf Ahmed Nossair1

  • 1Department of Ophthalmology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Kasr Alainy, Cairo, Egypt.

Journal of Ophthalmology
|February 22, 2018
PubMed

Insights

Accelerated collagen cross-linking (ACXL) improved vision and corneal transparency in pediatric keratoconus patients within one year. Corneal haze and densitometry returned to near baseline levels after 12 months.

Area of Science:

  • Ophthalmology
  • Corneal Science
  • Pediatric Eye Care

Background:

  • Pediatric keratoconus is a progressive thinning of the cornea, leading to visual impairment.
  • Early intervention is crucial to prevent advanced vision loss in children.

Purpose of the Study:

  • To assess the impact of accelerated collagen cross-linking (ACXL) on corneal transparency in children with progressive keratoconus.

Main Methods:

  • A prospective study involving 47 eyes of 25 pediatric patients (9-14 years) with keratoconus.
  • ACXL was performed after topical riboflavin application.
  • Evaluated visual acuity (UCVA, CDVA), corneal haze, and densitometry (GSU) over 12 months.

Main Results:

  • Corneal densitometry peaked at 3-8 months post-ACXL, returning to near baseline by 12 months.
  • Corneal haze peaked at 1 month and resolved significantly by 12 months.
  • Both UCVA and CDVA showed statistically significant improvement at 12 months.

Conclusions:

  • ACXL effectively improves corneal transparency and visual acuity in pediatric keratoconus patients.
  • Corneal haze and densitometry changes are temporary, with near-baseline values achieved after one year.
  • Scheimpflug densitometry showed a weak correlation with CDVA during the follow-up.
Abstract

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