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Inflammatory Biomarkers During Bacterial Acute Rhinosinusitis
Timo J Autio1,2,3, Timo Koskenkorva4,5,6, Petri Koivunen4,5,6
1Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, P.O. Box 21, FI-90029, OYS, Oulu, Finland. timo.autio@ppshp.fi.
Current Allergy and Asthma Reports
|February 22, 2018
Summary
Elevated C-reactive protein and erythrocyte sedimentation rate may indicate bacterial acute rhinosinusitis. However, these inflammatory biomarkers lack sensitivity for screening, necessitating careful diagnostic interpretation.
Area of Science:
- Otolaryngology
- Clinical Immunology
- Infectious Diseases
Background:
- Diagnosing bacterial acute rhinosinusitis presents significant clinical challenges.
- Inflammatory biomarkers offer potential insights into disease pathophysiology and diagnosis.
Purpose of the Study:
- To review and assess the literature on inflammatory biomarker profiles during acute rhinosinusitis.
- To evaluate the utility of inflammatory biomarkers in diagnosing bacterial acute rhinosinusitis.
Main Methods:
- Literature review of studies examining C-reactive protein, erythrocyte sedimentation rate, white blood cell counts, procalcitonin, and nasal nitric oxide.
- Analysis of biomarker levels in relation to bacterial acute rhinosinusitis diagnosis.
Main Results:
- Elevated C-reactive protein and erythrocyte sedimentation rate correlate with a higher likelihood of bacterial acute rhinosinusitis.
- Normal levels of these biomarkers are common, and elevated levels can occur in viral infections.
Conclusions:
- Elevated C-reactive protein and erythrocyte sedimentation rate can support bacterial acute rhinosinusitis diagnosis.
- These biomarkers lack the necessary sensitivity for screening patients for bacterial acute rhinosinusitis.
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