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Evaluation of adipokines in children with cystic fibrosis

Edyta Machura1, Maria Szczepańska, Elżbieta Świętochowska

  • 1Chair and Department of Pediatrics, Medical University of Silesia, School of Medicine with the Division of Dentistry, Poland, ul.3 Maja, 41-800 Zabrze, Poland. machurae@poczta.fm.

Endokrynologia Polska
|February 22, 2018
PubMed

Insights

Children with cystic fibrosis (CF) show higher resistin levels and lower adiponectin levels, indicating resistin may be a marker for inflammation and poorer lung function in CF patients.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Pulmonology

Background:

  • Cystic Fibrosis (CF) is associated with malnutrition, metabolic disturbances, and chronic inflammation.
  • These conditions may influence adipokine concentrations.

Purpose of the Study:

  • To investigate serum levels of resistin, apelin, and adiponectin in children with CF.
  • To assess the potential of these adipokines as inflammatory markers in CF.

Main Methods:

  • Comparison of serum adipokine levels (resistin, apelin, adiponectin) between children with CF and healthy controls.
  • Analysis of adipokine ratios (e.g., resistin/BMI, resistin/adiponectin) and their correlation with clinical parameters.

Main Results:

  • Children with CF had significantly higher resistin and lower adiponectin levels compared to controls.
  • Elevated resistin/BMI and resistin/adiponectin ratios were observed in CF patients.
  • Resistin levels and ratios correlated negatively with spirometric parameters like FEV1 and FVC.

Conclusions:

  • Increased resistin concentration and related ratios in CF children suggest its involvement in the inflammatory process.
  • Resistin may serve as a potential biomarker for airway obstruction severity in cystic fibrosis.
Abstract

Keywords:
adipokinesadiponectinapelinchildrencystic fibrosisinflammationresistin

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