Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dermatitis from quinazoline oxide.

P Rebandel, E Rudzki

    Contact Dermatitis
    |August 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Occupational dermatitis was identified in pharmaceutical workers exposed to quinazoline oxide, an intermediate in chlorodiazepoxide synthesis. Patch testing confirmed sensitization, with facial skin often more severely affected than hands.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Occupational contact dermatitis, with asthma and rhinitis, from camomile in a cosmetician also with contact urticaria from both camomile and lime flowers.

    Contact dermatitis·2003
    Same author

    Airborne contact dermatitis due to ethacridine lactate in a veterinary surgeon.

    Contact dermatitis·2001
    Same author

    Contact sensitivity to quinazoline oxide.

    Contact dermatitis·2001
    Same author

    Sensitivity to IPPD diagnosed a posteriori.

    Contact dermatitis·2001
    Same author

    Oral tolerance of nickel in patients with dyshidrosis.

    Contact dermatitis·2000
    Same author

    Decrease in frequency of occupational contact sensitivity to penicillin among nurses in Warsaw.

    Contact dermatitis·1999
    Same journal

    From Music to Eczema: Dermatitis Caused by Para-Phenylenediamine in a Violinist.

    Contact dermatitis·2026
    Same journal

    Reply to: Acrylate Copolymers/Crosspolymers in Sunscreens: Minimally Allergenic, Without Evidence of Need for Avoidance by (Meth)acrylate-Sensitized Individuals.

    Contact dermatitis·2026
    Same journal

    Contact Allergy and Allergic Contact Dermatitis From Propylene Glycol and Related Glycols: Cosmetic Skin Sensitisers After All?

    Contact dermatitis·2026
    Same journal

    Acrylate Copolymers/Crosspolymers in Sunscreens: Minimally Allergenic, Without Evidence of Need for Avoidance by (Meth)Acrylate-Sensitized Individuals.

    Contact dermatitis·2026
    Same journal

    AI-Assisted Automated Two-Stage Patch Test Interpretation System Using Vision Transformer.

    Contact dermatitis·2026
    Same journal

    Use of Tralokinumab in a Hairdresser With Severe Chronic Hand Eczema and Occupational Allergic Contact Dermatitis.

    Contact dermatitis·2026
    See all related articles

    Area of Science:

    • Chemical toxicology
    • Occupational dermatology
    • Pharmaceutical manufacturing safety

    Background:

    • Dermatitis is a common occupational hazard in pharmaceutical production.
    • Chemical intermediates can pose significant risks to worker health.
    • Chlorodiazepoxide synthesis involves potentially sensitizing compounds.

    Purpose of the Study:

    • To investigate cases of dermatitis in pharmaceutical workers.
    • To identify the causative agent of occupational dermatitis.
    • To assess the sensitization potential of a specific chemical intermediate.

    Main Methods:

    • Clinical observation of dermatitis in 29 workers.
    • Patch testing with quinazoline oxide at varying concentrations (1% and 0.05%).

    Related Experiment Videos

  • Correlation of exposure levels and work activities with dermatitis severity.

    • Main Results:

    • 29 pharmaceutical workers presented with dermatitis.
    • All workers showed positive patch test reactions to quinazoline oxide.
    • Facial dermatitis was more prevalent and severe than hand dermatitis.
    • Sensitization occurred even with indirect or limited contact.

    Conclusions:

    • Quinazoline oxide is a potent sensitizer causing occupational dermatitis.
    • Effective control measures are needed to prevent exposure in pharmaceutical manufacturing.
    • Dermatitis risk extends beyond direct handling to associated tasks.