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The Mouse Isolated Perfused Kidney Technique
Published on: November 17, 2016
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Morphologic and morphometric study on microvasculature of developing mouse kidneys.
Jie Zhang1, Jing Cong1,2, Jie Yang1
1Department of Histology and Embryology, Basic Medicine College, China Medical University , Shenyang , China.
American Journal of Physiology. Renal Physiology
|February 22, 2018
Summary
Proper kidney microvasculature development is key for kidney function and slowing chronic kidney disease. This study details early kidney vessel formation and growth, revealing its link to tubule development.
Area of Science:
- Nephrology
- Developmental Biology
- Vascular Biology
Background:
- Renal microvasculature development is critical for kidney function and mitigating chronic kidney disease progression.
- Existing knowledge of renal microvasculature morphogenesis is incomplete.
Purpose of the Study:
- To investigate the morphogenesis and volume densities of renal microvasculature during development.
- To understand the relationship between vascular and tubular development in the kidney.
Main Methods:
- Computer-assisted tubular tracing
- Immunohistochemistry for CD34
- Unbiased stereology
Main Results:
- Earliest glomerular capillaries form as loops in S-shaped nephrons, with parallel peritubular capillary establishment.
- Efferent arterioles and ascending vasa recta establish close proximity to specific tubule segments, forming medullary countercurrent relationships.
- Peritubular capillary volume density significantly increases from embryonic day 14.5 to postnatal day 40, while glomerular volume density shows minor changes.
Conclusions:
- Renal microvasculature morphogenesis involves early glomerular and peritubular capillary formation and specific vascular-tubular spatial arrangements.
- The development of the renal microvasculature, particularly peritubular capillaries, closely parallels the functional maturation of renal tubules.
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