Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
Position and Displacement01:31

Position and Displacement

The position of an object defines its location relative to a convenient frame of reference at any particular time. A frame of reference is an arbitrary set of axes from which the position and motion of an object are described. Earth is often used as a frame of reference, and we often describe the position of an object as it relates to stationary objects on Earth. For example, a rocket launch could be described in terms of the position of the rocket with respect to Earth as a whole. On the other...
Anatomical Movements00:51

Anatomical Movements

Anatomical movements refer to the various actions or motions that can be performed by the body's joints and muscles. These movements are described using specific terms to provide a standardized way of discussing and understanding the range of motion at different joints.
Here are some common anatomical movements:
Flexion and extension motions are in the sagittal (anterior–posterior) plane of motion. These movements take place at the shoulder, hip, elbow, knee, wrist, metacarpophalangeal,...
Upward Impending Motion01:21

Upward Impending Motion

A square-threaded screw jack is a mechanical device widely used for lifting heavy loads or applying considerable force. Its operation is based on converting the force applied at its handle into a torsional moment, causing the upward impending motion of the screw. This movement is accomplished by overcoming the static friction between the threads of the screw and the jack.
To better comprehend how a screw jack functions, consider the completely unraveled thread as a block in contact with the...
Position and Displacement01:31

Position and Displacement

The position of an object defines its location relative to a convenient frame of reference at any particular time. A frame of reference is an arbitrary set of axes from which the position and motion of an object are described. Earth is often used as a frame of reference, and we often describe the position of an object as it relates to stationary objects on Earth. For example, a rocket launch could be described in terms of the position of the rocket with respect to Earth as a whole. On the other...
Active Transport01:14

Active Transport

Active transport is a critical biological process that allows cells to move solutes against an electrochemical gradient. This process requires direct energy input and is characterized by its selectivity, saturability, and susceptibility to competitive inhibition.
Primary active transporters, like Na+, K+ and -ATPase, directly utilize ATP to move ions across the membrane. These transporters play significant roles in various physiological processes. For instance, Na+, K+ and -ATPase maintain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synchronization of the 12-hour circatidal rhythm maintains the kidney through repeated cycles of warm reperfusion in the hibernating ground squirrel.

Function (Oxford, England)·2026
Same author

Adrenal gene expression dynamics support hibernation in 13-lined ground squirrels.

Physiological genomics·2023
Same author

Dynamic temperature-sensitive A-to-I RNA editing in the brain of a heterothermic mammal during hibernation.

RNA (New York, N.Y.)·2018
Same journal

Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy.

eLife·2026
Same journal

Analysis of dendritic input currents during place field dynamics.

eLife·2026
Same journal

TopoMetry systematically learns and evaluates the latent geometry of single-cell data.

eLife·2026
Same journal

Navigating the path: Advice to physician-scientists on choosing a clinical specialty.

eLife·2026
Same journal

Neural activity profiles reveal overlapping, intermingled subpopulations spanning area borders in mouse sensorimotor cortex.

eLife·2026
Same journal

The exquisite mechanics of a tsetse bite.

eLife·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Identification of Fatty Acids in Bacillus cereus
08:41

Identification of Fatty Acids in Bacillus cereus

Published on: December 5, 2016

10.1K

On the move.

Sandra L Martin1

  • 1Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, United States.

Elife
|February 22, 2018
PubMed
Summary
This summary is machine-generated.

Long Interspersed Nuclear Element-1 (LINE-1) retrotransposon duplication mechanisms are increasingly understood. Research is clarifying how these mobile genetic elements propagate throughout the human genome.

Keywords:
LINE-1ORF1pORF2pcell biologycell cycleevolutionary biologygenomicshumanretrotransposonvirus

More Related Videos

A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans
08:49

A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans

Published on: March 20, 2018

9.4K
Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates
08:32

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates

Published on: October 25, 2018

9.6K

Related Experiment Videos

Last Updated: Jun 25, 2026

Identification of Fatty Acids in Bacillus cereus
08:41

Identification of Fatty Acids in Bacillus cereus

Published on: December 5, 2016

10.1K
A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans
08:49

A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans

Published on: March 20, 2018

9.4K
Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates
08:32

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates

Published on: October 25, 2018

9.6K

Area of Science:

  • Genomics
  • Molecular Biology
  • Human Genetics

Background:

  • Retrotransposons are mobile genetic elements comprising a significant portion of the human genome.
  • LINE-1 elements are autonomous retrotransposons capable of autonomous retrotransposition.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying LINE-1 retrotransposon replication.
  • To understand the process of LINE-1 proliferation within the human genome.

Main Methods:

  • Molecular cloning and sequencing of LINE-1 elements.
  • Cell-based assays to study LINE-1 activity.
  • Bioinformatic analysis of genomic distribution.

Main Results:

  • Key proteins and cellular factors involved in LINE-1 duplication have been identified.
  • Specific steps in the LINE-1 retrotransposition cycle are being delineated.
  • Patterns of LINE-1 insertion across the human genome are being characterized.

Conclusions:

  • The understanding of LINE-1 retrotransposon biology is advancing.
  • These findings provide insights into genome dynamics and potential roles in human disease.