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Pathologic Features of Infectious Gastritis.

Eric U Yee1, Enoch Kuo1, Jeffrey D Goldsmith2

  • 1Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR.

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This review focuses on infectious gastritis for pathologists, detailing unique histological findings and clinical features in stomach biopsies. It aids in diagnosing infections from endoscopic samples and surgical resections.

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Area of Science:

  • Gastroenterology
  • Anatomic Pathology
  • Infectious Diseases

Background:

  • Gastritis is a common gastrointestinal condition with diverse etiologies.
  • Infectious agents are significant contributors to gastritis, often presenting with subtle or overlapping clinical features.
  • Accurate diagnosis is crucial for appropriate patient management and preventing complications.

Purpose of the Study:

  • To provide practicing anatomic pathologists with a comprehensive review of infectious causes of gastritis.
  • To highlight key histologic findings and clinical attributes associated with various infectious agents.
  • To assist in the interpretation of endoscopically obtained gastric mucosal biopsies and resection specimens.

Main Methods:

  • Literature review of infectious gastritis.
  • Analysis of unique histopathological features.
  • Correlation of histological findings with clinical presentations.

Main Results:

  • Detailed description of characteristic histological patterns for common and uncommon infectious gastritis.
  • Emphasis on differentiating infectious causes from non-infectious gastritis.
  • Identification of specific stains and molecular techniques useful for pathogen detection.

Conclusions:

  • Infectious gastritis requires careful histopathological evaluation.
  • Recognizing unique histologic clues is essential for accurate diagnosis.
  • Pathologists play a critical role in identifying infectious etiologies of gastritis, guiding clinical treatment.