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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
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Liver involvement in dengue viral infections
Harsha A Dissanayake1, Suranjith L Seneviratne2,3
1University Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Reviews in Medical Virology
|February 22, 2018
Summary
Dengue fever commonly causes liver injury, which is more severe in dengue hemorrhagic fever cases. This review explores dengue
Area of Science:
- * Tropical Medicine
- * Hepatology
- * Infectious Diseases
Background:
- * Dengue fever is a prevalent viral hemorrhagic fever in tropical regions.
- * Liver injury is a common complication of dengue viral infections.
- * Severity of liver injury correlates with dengue hemorrhagic fever and severe dengue.
Purpose of the Study:
- * To review current knowledge on liver involvement in dengue viral infections.
- * To explore the relationship between clinical manifestations and liver injury.
- * To investigate the pathogenesis of dengue-associated liver injury and its management implications.
Main Methods:
- * Comprehensive literature review of studies on dengue and liver injury.
- * Analysis of clinical data and case reports.
- * Exploration of immunological and virological mechanisms.
Main Results:
- * Dengue infections frequently lead to varying degrees of hepatic dysfunction.
- * Severe dengue cases exhibit more pronounced liver injury.
- * Pathogenesis involves direct viral effects and immune-mediated responses.
Conclusions:
- * Liver injury is a significant clinical feature of dengue fever.
- * Understanding pathogenesis is crucial for improved patient management.
- * Further research is needed to optimize treatment strategies for dengue-associated liver injury.
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