The pharmacokinetics of alpha-human atrial natriuretic polypeptide in healthy subjects

We have analysed the pharmacokinetics of alpha-human atrial natriuretic polypeptide (alpha-hANP) in healthy subjects, using a two-compartment open model following bolus intravenous injection. The plasma half-times for the fast and slow components were 1.7 +/- 0.07 min and 13.3 +/- 1.69 min respectively. V1 (the volume of the central compartment), VZ (volume of distribution) and VSS (volume of distribution at steady-state) were 5370 +/- 855 ml (89.5 +/- 14.3 ml X kg-1), 32000 +/- 4620 ml (533 +/- 77.0 ml X kg-1), and 11900 +/- 1530 ml (198 +/- 25.5 ml X kg-1) respectively. The mean plasma clearance was 1520 +/- 121 ml X min-1 (25.4 +/- 2.0 ml X min-1 X kg-1.