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Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
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Targeting the Proteostasis Network for Mycobacterial Drug Discovery

Tania J Lupoli1, Julien Vaubourgeix1, Kristin Burns-Huang1

  • 1Department of Microbiology and Immunology , Weill Cornell Medicine , 413 East 69th Street , New York , New York 10021 , United States.

ACS Infectious Diseases
|February 22, 2018
PubMed

Keywords:
Mycobacterium tuberculosisantibioticschaperoneshost immunityproteasesproteasomeprotein aggregationprotein foldingprotein misfoldingproteolysisproteostasisproteostasis network

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