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Updated: Feb 14, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
Published on: September 15, 2018
[Assessment of Vascular Stiffness in Normotensive Patients With Familial Hypercholesterolemia]
V A Korneva1, T Y Kuznetsova1, G P Tikhova1
1Petrozavodsk State University.
Aim:
to analyze parameters of vascular stiffness and augmentation index in patients with familial hypercholesterolemia (FH).
Materials And Methods:
We compared parameters of vascular stiffness of 88 normotensive FH patients (mean age 41.95±1.43 years, 43 men [48.9 %]) and 68 subjects with normal blood lipid spectrum (mean age 37.58±1.02 years, 21 men [30.9 %]). FH was diagnosed according to the criteria of the Dutch Lipid Clinic Network. Examination included lipid profile, 24‑hour blood pressure (BP) monitoring with assessment of arterial stiffness.
Results:
Normotensive FH patients had higher pulse wave velocity (PWV) (7.99±0.17 m/s) in comparison with patients with normal lipid spectrum (6.87±0.10 m/s), p.
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