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Siderophore production by Pasteurella multocida.

S P Hu, L J Felice, V Sivanandan

    Infection and Immunity
    |December 1, 1986
    PubMed
    Summary
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    Pasteurella multocida produces a novel siderophore, multocidin, under iron-limited conditions. This growth factor aids bacterial survival and represents the first identified siderophore from this species.

    Area of Science:

    • Microbiology
    • Bacterial Physiology
    • Biochemistry

    Background:

    • Pasteurella multocida is a significant bacterial pathogen.
    • Iron is an essential nutrient for bacterial growth.
    • Siderophores are crucial for iron acquisition in many bacteria.

    Purpose of the Study:

    • To investigate iron-regulated growth factors secreted by Pasteurella multocida.
    • To characterize the chemical nature of a novel secreted growth-enhancing factor.

    Main Methods:

    • Culturing Pasteurella multocida under iron-deprived conditions.
    • Chemical testing and bioassays to identify the factor's properties.
    • Partial purification of the secreted compound.

    Main Results:

    Related Experiment Videos

    • Pasteurella multocida secretes a growth-enhancing factor under iron limitation.
    • The factor functions as a siderophore.
    • The siderophore, named multocidin, is not a phenolate or hydroxamate.
    • Multocidin is polar, nonaromatic, and dialyzable.

    Conclusions:

    • This study demonstrates, for the first time, siderophore production by Pasteurella multocida.
    • The novel siderophore, multocidin, plays a role in iron acquisition for P. multocida.
    • Multocidin's unique chemical properties warrant further investigation.