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Related Concept Videos

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

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At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
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¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR01:15

¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

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The axial and equatorial protons in cyclohexane can be distinguished by performing a variable-temperature NMR experiment. In this process, except for one proton, the remaining eleven protons are replaced by deuterium. The deuterium substitution avoids the possible peak splitting caused by the spin-spin coupling between the adjacent protons. The remaining proton flips between the axial and equatorial positions.
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The Representativeness Heuristic02:13

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The representative heuristic describes a biased way of thinking, in which you unintentionally stereotype someone or something. For example, you may assume that your professors spend their free time reading books and engaging in intellectual conversation, because the idea of them spending their time playing volleyball or visiting an amusement park does not fit in with your stereotypes of professors.
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Longitudinal Research02:20

Longitudinal Research

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
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Novel β-L-2'-deoxyribonucleoside Reverse Fleximers with Inhibitory Activity Against HBV, BKV, and Other Viruses.

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New Flexible Analogues of 8-Aza-7-deazapurine Nucleosides as Potential Antibacterial Agents.

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Related Experiment Video

Updated: Feb 14, 2026

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
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Flexibility-Not just for yoga anymore!

Katherine Seley-Radtke1

  • 1Department of Biochemistry and Chemistry, University of Maryland, Baltimore, MD, USA.

Antiviral Chemistry & Chemotherapy
|February 23, 2018
PubMed
Summary

Nucleoside analogs are vital for antiviral and anticancer drugs. This study introduces fleximers, a novel class of nucleosides with flexibility in the nucleobase scaffold, expanding therapeutic design options.

Area of Science:

  • Medicinal Chemistry
  • Nucleoside Analog Therapeutics
  • Drug Design

Background:

  • Nucleosides are foundational in antiviral and anticancer therapies.
  • Modifications to the sugar moiety, like in tenofovir, have yielded successful drugs.
  • Flexibility in the nucleobase scaffold represents a newer, significant avenue in nucleoside drug design.

Purpose of the Study:

  • To detail the history and development of fleximers, a novel class of nucleoside analogs.
  • To explore the biological relevance and therapeutic potential of fleximers.
  • To highlight the innovation of introducing flexibility to the nucleobase scaffold.

Main Methods:

  • Review of historical development of nucleoside analog drug design.
  • Introduction and characterization of fleximer compounds.
Keywords:
Coronaviridaedengue virusfiloviridaeflaviviridaenucleoside analogues

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  • Assessment of biological relevance and potential applications.

    • Main Results:

    • Fleximers represent a significant advancement by incorporating flexibility into the nucleobase.
    • This innovation offers new possibilities for nucleoside-based therapeutics.
    • The study provides insights into the development and biological significance of these compounds.

    Conclusions:

    • Fleximers offer a promising new direction in nucleoside drug discovery.
    • The flexibility in the nucleobase scaffold expands the therapeutic utility of nucleoside analogs.
    • Further research into fleximers is warranted for antiviral and anticancer applications.